Hi,
Ok that should be possible.
Firstly what certificates have you got on the server? Does it cover the mail2.domain.com URL.
Secondly have you got an A record in your internal DNS for mail2.domain.com?
Finally if all the above are OK, you can change the InternalURL field for the various virtual directories so it uses the mail2.domain.com URL.
Post back with the answers to the above and I will send a script which will make the changes when I am at work tomorrow.
Cheers
Nathan
Nathan Winters - MVP Exchange Server
MCSE & MCSA 2000 & 2003 + Messaging, MCITP Exchange 2007, MCP, VMWare VCP v2 & v3.
Welcome to the Microsoft Messaging and Mobility User Group: http://www.mmmug.co.uk